ABSTRACT
ObjectiveTo investigate the effects of different acupuncture schemes on behaviors, neurotransmitters and inflammation-related factors in post-stroke depressed (PSD) rats. MethodsA total of 72 healthy male Sprague-Dawley rats were randomly divided into normal group, model group, drug control group, scalp acupuncture group, abdominal acupuncture group and combined acupuncture group, 12 rats in each group. The PSD model was prepared using a combination of middle cerebral artery occlusion and chronic unpredictable mild stimulation (CUMS) for the model and each intervention groups. The drug control group was administered fluoxetine, the scalp acupuncture group accepted acupuncture at Baihui (DU 20) and Yintang (EX-HN3), while the abdominal acupuncture group at Zhongwan (RN 12) and Guanyuan (RN 4), the combined acupuncture group at all the four acupoints, for 21 days. They were assessed with Longa neurological function score, body mass, open-field test and sugar-water preference test on the 0 (before modeling), the seventh (before CUMS), the 14th (before treatment) and the 35th day (after treatment). The levels of 5-hydroxytryptamine (5-HT), dopamine (DA), norepinephrine (NE), interferon-γ (INF-γ), tumor necrosis factor⁃α (TNF⁃α) and macrophage migration inhibitory factor (MIF) in the serum were determined with ELISA on the 35th day. Results The neurological function score was lower in the drug control group and the combined acupuncture group thanin the model group (P < 0.01) on the 35th day; while the body mass was higher in the drug control group, the abdominal acupuncture group and the combined acupuncture group than in the model group (P < 0.01); and the number of horizontal span frames, the number of uprightness and the sugar water consumption were higher in the drug control group, the scalp acupuncture group, the abdominal acupuncture group and the combined acupuncture group than in the model group (P < 0.05). There was no significant difference among the four intervention groups (P > 0.05). The levels of 5-HT, DA and NE were higher in the four intervention groups than in the model group (P < 0.01), and the levels of IFN-γ, TNF⁃α and MIF were lower (P < 0.01). 5-HT level was higher in the combined acupuncture group than in the scalp acupuncture group and the abdominal acupuncture group, and the levels of IFN-γ, TNF⁃α and MIF were lower (P < 0.01); the levels of DA and NE was higher in the combined acupuncture group than in the abdominal acupuncture group (P < 0.01). ConclusionThe combination of scalp acupuncture and abdominal acupuncture can improve behavior, neurotransmitters and inflammatory factors of PSD rats, like fluoxetine. Scalp or abdominal acupuncture alone is still effecive, and can be used secondarily.
ABSTRACT
Objective To compare the effect of electroacupuncture applied to different locations of body on the detrusor pressure of de-trusor areflexia neurogenic bladder post spinal cord injury (SCI) to find optimal locations for electroacupuncture. Methods 108 incomplete SCI patients were selected following International Standards for Neurological Classification of Spinal Cord Injury (ASIA 2006) and random-ly assigned to urethral catheterization group, control group, and experiment group with 36 cases in each group. The urethral catheterization group was only given intermittent catheterization, the control group was given electroacupuncture of Baliao (BL31 to BL34) and Huiyang (BL35) as the main points and intermittent catheterization, and the experiment group was treated with transcranial electrical stimulation of foot motor sensory area and Abdominal Area Six as the main points and intermittent catheterization. They were assessed with voiding diary and urodynamic test before and after treatment. Results There were significant differences among the urethral catheterization group, the con-trol group, and the experiment group in automatic micturition volume, urethral catheter output and residual urine volume after treatment (P0.05). There was significant difference in detrusor pressure and reflection in the urethral catheterization group from both the control group and the experiment group after treatment (P<0.05). Conclusion Electroacupunc-ture can promote automatic micturition in patients with detrusor areflexia neurogenic bladder after incomplete SCI.
ABSTRACT
@#(SCI) to find optimal locations for electroacupuncture. Methods 108 incomplete SCI patients were selected following International Standards for Neurological Classification of Spinal Cord Injury (ASIA 2006) and randomly assigned to urethral catheterization group, control group, and experiment group with 36 cases in each group. The urethral catheterization group was only given intermittent catheterization, the control group was given electroacupuncture of Baliao (BL31 to BL34) and Huiyang (BL35) as the main points and intermittent catheterization, and the experiment group was treated with transcranial electrical stimulation of foot motor sensory area and Abdominal Area Six as the main points and intermittent catheterization. They were assessed with voiding diary and urodynamic test before and after treatment. Results There were significant differences among the urethral catheterization group, the control group, and the experiment group in automatic micturition volume, urethral catheter output and residual urine volume after treatment (P<0.05). Detrusor pressure and reflection was significantly different in the control group and the experiment group before and after treatment (P<0.05), but not in the urethral catheterization group (P>0.05). There was significant difference in detrusor pressure and reflection in the urethral catheterization group from both the control group and the experiment group after treatment (P<0.05). Conclusion Electroacupuncture can promote automatic micturition in patients with detrusor areflexia neurogenic bladder after incomplete SCI.
ABSTRACT
Chinese Medical therapy such as herbal treatment, acupuncture were used in rehabilitaion for spinal cord injury and proved effective. It is important to explore the advantage and disadvantage of them.
ABSTRACT
Along with the development of the society,the herbal dosage was developed from the uncertainty and imprecisionin primary formulae to relatively exactness in classical formulae of Treatise on Cold Pathogenic Diseases and Miscellaneous Diseases(Shanghan Zabing Lun);it embodied the medicinal development.Due to the vicissitudes of metrology in past dynasties,doctors applied the classical formulae were opinions differ from each other,formed the different recognitions of later ages on dosage conversions in classical formulae;it in a certain extent influenced the accurate inheritance of classical formulae.There was no agreement among many views on dosage conversions of the classical formulae all the times and it was suspense.The definition of dosage in classical formulae properly had its fact evidences,and it must be based on therapeutic effect.Through the cognition of relevant discussions and the textual research on weights and measures in modern time et al,it was quite helpful for the definition of dosage conversions;meanwhile it had important significance to research on dosage conversions in classical formulae assisted with demonstration method.